Abstract
It is increasingly perceived that dietary components have been linked with the prevention of intestinal cancer. Cranberry is a rich source of phenolic constituents and non-digestible fermentable dietary fiber, which shows anti-proliferation effect in colorectal cancer cells. Herein, we investigated the efficacy of long-term cranberry diet on intestinal adenoma formation in Apcmin/+ mice. Apcmin/+ mice were fed a basal diet or a diet containing 20% (w/w) freeze-dried whole cranberry powder for 12 weeks, and the number and size of tumors were recorded after sacrifice. Our results showed that cranberry strongly prevented the growth of intestinal tumors by 33.1%. Decreased cell proliferation and increased apoptosis were observed in tumors of cranberry-fed mice. Cranberry diet reduced the expression profile of colonic inflammatory cytokines (IFN-γ, IL-1β and TNF-α) accompanied with increased levels of anti-inflammatory cytokines (IL-4 and IL-10). Moreover, the number of colonic goblet cells and MUC2 production were increased, and the intestinal barrier function was also improved. In addition, cranberry diet increased caecal short chain fatty acids concentrations, and down-regulated epidermal growth factor receptor signaling pathway. These data firstly show the efficacy and associated mechanisms of cranberry diet on intestinal tumor growth in Apcmin/+ mice, suggesting its chemopreventive potential against intestinal cancer.
Highlights
Clinical data provide an overview that colorectal cancer (CRC) has become the one of the most commonly diagnosed tumors in the overall population [1, 2]
We found that the addition of cranberry diet to Apcmin/+ mice made no significant difference in the weight of caecal content ( p > 0.05, Table 1)
The present study showed the inhibitory effects of feeding cranberry supplemented diet on the intestinal polyposis in the Apcmin/+ mouse model, which justified further research about how berry phytonutrients prevented CRC in vivo
Summary
Clinical data provide an overview that colorectal cancer (CRC) has become the one of the most commonly diagnosed tumors in the overall population [1, 2]. There is evidence to suggest that cranberry phytochemicals have anticancer properties such as limiting prostate tumorigenesis and metastasis [5,6,7]. It has been observed that cranberry consumption in patients with prostate cancer decreased the level of serum prostate specific antigen [8] and the incidence of radiation cystitis [9]. Cranberry derived phytochemicals have been evaluated to be antineoplastic compounds in many tumor cell lines, such as in human breast cancer cells [10], lung cancer cells [11], ovarian cancer cells [12, 13], bladder cancer cells [14] and even esophageal adenocarcinoma cell lines [15, 16]. Www.impactjournals.com/oncotarget freeze-dried cranberry powder diet has been reported to alleviate inflammatory response and lipid oxidation, which is useful to individuals with the metabolic syndrome [17, 18]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
