Dietary fat intake and plasma homocysteine in human immunodeficiency virus‐infected patients (810.3)

Abstract

Objective: Hyperhomocysteinemia (HHcy) is associated with increased cardiovascular risk. We assessed the relationship between diet and plasma homocysteine (Hcy) in HIV‐infection.Methods: After consenting, plasma Hcy, folate, and vitamin B12 were obtained from 291 HIV+ adults. HHcy was defined as Hcy>12 µmol/L. 24‐hour food recalls were analyzed using Nutribase 9.0; ART use was collected. Linear and Logistic regressions were used.Results: Mean age was 44.92 years, 65% were men, 69.8% Black, and 81% were on ART; 22.7% had HHcy. Participants not on ART had higher saturated fat intake (33.64±28.42 vs. 25.41±20.54 g, P=0.045) and higher plasma Hcy levels (11.14±2.90 vs. 10.04±3.97 μmol/L, P= 0.053) than those on ART. Hcy levels were positively correlated with total fat (β=0.011, SE=0.004, p=0.020) and saturated fat intake (β=0.029, SE=0.013, p=0.036). Among those on ART, Hhcy was associated with high systolic blood pressure (OR=2.17, 95% CI: 1.112, 4.251, p=0.023).Conclusion: HHcy is associated with higher total fat and saturated fat intake in HIV+ adults not ART. Among those on ART, Hcy was not associated with diet, but with hypertension. Interventions should be tailored to address increased fat intake and hypertension in the HIV+ population.Grant Funding Source: NIAAA