Abstract
IntroductionFumonisins are a group of widespread mycotoxins mainly existing in staple foods. Their toxicological effects on humans cause worldwide public health threat. During 2015–2020, the 6th China Total Diet Study (TDS) was conducted to study the dietary exposure to fumonisins in the Chinese adult population.MethodsFumonisins were analyzed by LC-MS/MS in 288 composite dietary samples collected from 24 provincial-level administrative divisions. After combining the national consumption data with analytical results, estimated daily intakes (EDIs) were assessed and compared with health-based guide values (HBGV).ResultsIn the 6th China TDS, the highest fumonisin B (FBs) levels were found in staple foods/cereals among the 12 food categories. EDI of FBs was 104.9 ng/kg of body weight (bw)/day at the upper bound accounting 5.25% of the provisional maximum tolerable daily intake set by Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives. Among the 12 food categories, cereals and cereal products were the greatest contributor to FB exposure at 95%.ConclusionAlthough the estimated exposure to FBs in the 6th China TDS were well below the HBGV for FBs in general, it was 2 times higher than the exposure in the 5th China TDS. Furthermore, the exposure to FB3 has increased remarkable and is worth further attention in China.
Highlights
Fumonisins are a group of widespread mycotoxins mainly existing in staple foods
As being possibly carcinogenic in humans (Group 2B) [1], fumonisin B1 (FB1) has been shown to cause a variety of diseases in animals, including hepatotoxic, nephrotoxic, hepatocarcinogenic, and cytotoxic effects in mammals [2] with high potential impact on human health [3]
In order to assess the risk of Fumonisin B (FB) dietary intake in China, we applied a total diet study (TDS) approach
Summary
Fumonisins are a group of widespread mycotoxins mainly existing in staple foods. Their toxicological effects on humans cause worldwide public health threat. During 2015–2020, the 6th China Total Diet Study (TDS) was conducted to study the dietary exposure to fumonisins in the Chinese adult population. To protect human health from the risk of FBs, the Joint Food and Agriculture Organization (FAO)/World Health Organization (WHO) Expert Committee on Food Additive (JECFA) has set a provisional maximum tolerable daily intake (PMTDI) for the group of fumonisins (B1 and its analogues B2 and B3), at 2 μg/kg of body weight (bw)/day [4]. In order to assess the risk of FB dietary intake in China, we applied a total diet study (TDS) approach. TDS has been conducted in several countries and regions for mycotoxin exposure assessment [9]
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