Abstract
Eight-month-old male Sprague Dawley rats were fed diets containing α-tocopherol (Toc) or tocotrienol (T3) mixture (composed of 20.5% α-Toc, 21.4% α-T3, 36.5% γ-T3 and other analogs) at the 0.1 or 0.5% level for 3 weeks to examine their dietary effects on lipid metabolism and immune indices. Feeding of α-Toc and T3 significantly de-creased liver phosphatidylcholine peroxide and serum phospholipid levels. In the regulation of immunoglobulin level, significant increase in serum IgA level was observed in the rats fed α-Toc or T3, but the effect on immunoglobulin productivity from spleen and mesenteric lymph node (MLN) was not as marked. Feeding of α-Toc and T3 significantly decreased LTB4-releasing activity of peritoneal exudate cells without decreasing arachidonic acid level. The suppression of LTB4 release was more marked in the rats fed 0.1% α-Toc or T3 than in these fed them at the 0.5% level. When animals were killed after 10 h of fasting, T3 was detected only in MLN and epidydimal adipose tissue. These results suggest that T3 modulates lipid metabolism and immune functions as well as α-Toc, and that MLN and adipose tissue are the main target tissues of T3.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
