Abstract
Aflatoxin B1 (AFB1) is a stable toxic metabolite threatening health of human and animal and widely contaminated animal feed and human food. This present study aimed to investigate the effects of dietary curcumin on ileum injury in ducks induced by AFB1 administration and explore its underlying mechanisms. Ducks (N = 450, one-day-old male) with a similar weight were randomly assigned to 3 groups, containing the control group, AFB1 group (60 μg AFB1 kg−1 body weight) and curcumin (500 mg curcumin kg−1 diet) + AFB1 group. AFB1 administration markedly increased the ileum damage, AFB1-DNA adducts in the plasma and oxidation stress and inflammation. Adding curcumin into diet protected the ileum against morphology damage induced by AFB1 administration, decreased AFB1-DNA adducts in the plasma and eliminated oxidation stress and inflammation in the ileum of ducks. Anti-oxidation and anti-inflammatory effects of curcumin could protect the ileum against acute damage via activating Nrf2-ARE signaling pathway and inhibiting NF-κB signaling pathway. Conclusively, curcumin was a dietary anti-oxidation and anti-inflammation agent via activating Nrf2-ARE signaling pathway and inhibiting NF-κB signaling pathway to protect ileum against acute damage induced by AFB1 administration.
Highlights
Meat is an important source of high-quality protein for human nutrition
Compared to the T0 group, Aflatoxin B1 (AFB1) administration significantly increased the content of AFB1-DNA adducts (p < 0.001) in the plasma
Dietary curcumin promoted Nrf2 downstream genes expression such as antioxidant genes (CAT, SOD1, GPX1, GST) and phase II detoxifying enzyme genes (NQO1, HO-1, GCLC, GCLM), which demonstrated that adding curcumin into diet for ducks inhibited the acute oxidation damage of ileum induced by AFB1 administration through activating Nrf2-antioxidant response element (ARE) signaling pathway Results in this study provided an evidence that dietary curcumin could be a potent ameliorating agent to protect ileum against oxidation stress induced by AFB1 administration
Summary
Meat is an important source of high-quality protein for human nutrition. Duck meat is abundantly consumed worldwide, especially in Asia because of its desirable nutritional characteristics [1]. There are various disadvantages in the breeding process, such as AFB1 that threaten the health of ducks. AFB1 is recognized as the most toxic among aflatoxin (AF) groups, along with an assortment of toxic effects to threat the health of human and animals [2]. Food or feed is a common and important way to exposure to AFB1, but inhalation and direct contact with skin or mucosa contact are counted and not ignored [3]. Tissue and organ damages induced by AFB1 administration related to oxidation stress and inflammation. The variation of functionality and morphology may be attributed to the process of toxin metabolism that is often accompanied by oxidative stress and inflammation. AFB1 is one of the foremost concerns in poultry industry due to its potent toxicity
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