Abstract
The healing of any injury requires a dynamic balance of initiation and resolution of inflammation. This hypothesis-generating review presents an overview of the various nutrients that can act as signaling agents to modify the metabolic responses essential for the optimal healing of injury-induced inflammation. In this hypothesis-generating review, we describe a defined nutritional program consisting of an integrated interaction of a calorie-restricted anti-inflammatory diet coupled with adequate levels of omega-3 fatty acids and sufficient levels of dietary polyphenols that can be used in clinical trials to treat conditions associated with insulin resistance. Each dietary intervention works in an orchestrated systems-based approach to reduce, resolve, and repair the tissue damage caused by any inflammation-inducing injury. The orchestration of these specific nutrients and their signaling metabolites to facilitate healing is termed the Resolution Response. The final stage of the Resolution Response is the activation of intracellular 5' adenosine monophosphate-activated protein kinase (AMPK), which is necessary to repair tissue damaged by the initial injury-induced inflammation. The dietary optimization of the Resolution Response can be personalized to the individual by using standard blood markers. Once each of those markers is in their appropriate ranges, activation of intracellular AMPK will be facilitated. Finally, we outline how the resulting activation of AMPK will affect a diverse number of other intercellular signaling systems leading to an extended healthspan.
Highlights
There are two distinct phases to the body’s response to any injury: the initiation of inflammation and its resolution
The healing of any injury requires a dynamic balance of initiation and resolution of inflammation. This hypothesis-generating review presents an overview of the various nutrients that can act as signaling agents to modify the metabolic responses essential for the optimal healing of injury-induced inflammation. In this hypothesis-generating review, we describe a defined nutritional program consisting of an integrated interaction of a calorie-restricted anti-inflammatory diet coupled with adequate levels of omega-3 fatty acids and sufficient levels of dietary polyphenols that can be used in clinical trials to treat conditions associated with insulin resistance
We hypothesize that the ability to heal from any injuryinduced inflammation depends significantly on the dietary control of the body’s internal Resolution Response
Summary
There are two distinct phases to the body’s response to any injury: the initiation of inflammation and its resolution. Changes in the insulin-glucagon balance can affect the activity of various desaturases are critical for preventing excess arachidonic acid production [14] These initial results suggest that the protein-tocarbohydrate balance of a calorie-restricted diet may significantly improve its anti-inflammatory effects. This need for potential supplementation is because the levels of omega-3 fatty acids in the blood required to resolve the residual inflammation caused by the injury sufficiently are often beyond the intake provided by the best antiinflammatory diet This need for supplementation is the case for the amounts of polyphenols needed to activate AMPK to repair damaged tissue. The continuous optimization of the Resolution Response by the diet may play an essential role in extending the human healthspan
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