Abstract
ABSTRACTMice consumed diets which contained caffeine and predominated in either corn starch, sucrose or hydrogenated vegetable oil. When compared by means of an oral glucose tolerance test to mice which had eaten the same diets without caffeine, it was found that they had a more rapid return of blood glucose to resting values. In vivo measurements of glucose uptake by diaphragm and epididymal fat pad revealed differences in this adaptation to caffeine. The adaptive mechanism appeared to vary with type of diet. When mice were given caffeine chronically in their drinking water there was evidence of adaptation occurring in the ability of muscle to increase glycogen stores in the presence of caffeine in vitro. No differences were found in other tissue glycogen levels.
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