Abstract
The present study is aimed to explore the effects of different dietary beta-hydroxy-beta-methyl butyrate (HMB) levels (0, 0.05%, 0.10%, or 0.15%) on liver lipid metabolism on Wenshi broiler chickens. Results showed that HMB reduced the liver weight as well as liver concentrations of triacylglycerol (TG) and total cholesterol (TC) (quadratically, p < 0.05), and the lowest values were observed in the 0.10% HMB group. Meanwhile, HMB supplementation significantly altered the expression levels of key genes related to lipid metabolism in the liver of broiler chickens (p < 0.05). Furthermore, 16S rRNA gene sequencing revealed that HMB supplementation could greatly change the richness, diversity, and composition of the broiler gut microbiota, and the Bacteroidetes relative abundance at the phylum level and the Alistipes relative abundance at the genus level were affected (p < 0.05). Correlation analysis further suggested a strong association between Bacteroidetes relative abundance and lipid metabolism-related parameters (p < 0.05). Together, these data suggest that 0.10% HMB supplementation could inhibit hepatic fat deposition via regulating gut microbiota in broilers.
Highlights
Publisher’s Note: MDPI stays neutralIn recent years, with the improvement of living standards, public demands for safe, healthy, and high-quality meat in human diets are increasing [1]
In order to investigate whether hydroxy-betamethyl butyrate (HMB) supplementation regulated lipid metabolism in broiler chickens, we first measured the liver weight, abdominal fat percentage, and liver
Gut microbiota are closely related to lipid metabolism, we investigated the composition of the cecal microbiota in broiler chickens
Summary
Publisher’s Note: MDPI stays neutralIn recent years, with the improvement of living standards, public demands for safe, healthy, and high-quality meat in human diets are increasing [1]. The rapid growth of modern broilers can increase the liver load, leading to a higher risk of fat accumulation in the liver [3]. The increase of fat deposition in peripheral tissues (especially the abdominal adipose tissue) will lead to a reduction in meat quality and an increase in feed cost [6]. Excessive abdominal fat deposition-induced economic losses are estimated to be over $2.7 billion [2]. In this context, one effective way to reduce economic losses of many poultry producers is to inhibit fat synthesis and deposition in with regard to jurisdictional claims in published maps and institutional affiliations
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