Abstract
Atopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells. Arctium lappa L. is a traditional medicine in Asia. This study examined the effect of ALBE (butanolic extracts of A. lappa) on the release of β‐hexosaminidase in antigen‐stimulated‐RBL‐2H3 cells and the expression of IL‐4, IL‐5, pMAPKs, and NF‐κB activation in ConA‐stimulated splenocytes. We observed significant inhibition of β‐hexosaminidase release, the production of IL‐4 and IL‐5, NF‐κB translocation and the phosphorylation of MAPKs. Additionally, ALBE suppressed the expression of ICAM‐1 and the production of NO‐iNOS induced by TNF‐α in A549 endothelial cells. These results suggest that ALBE may have beneficial effects in the treatment of allergic diseases, including atopic dermatitis. This study was supported by Technology Development Program for Agriculture and Forestry, Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea.
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