Dietary antioxidants associated with slower progression of parkinsonian signs in older adults

Abstract

ABSTRACT Background and Objective: Progressive loss of motor function including parkinsonian signs is common in older adults. As diet may contribute to the motor decline, we tested the hypothesis that dietary intake of antioxidant nutrients (carotenoids, vitamin E and vitamin C) is related to the progression of parkinsonian signs in older adults. Research Design and Methods: A total of 682 participants without a clinical diagnosis of Parkinson’s Disease from the Rush Memory and Aging Project, were assessed annually over an average of 5.7 (±3.0) years using a 26-item modified version of the United Parkinson’s Disease Rating Scale. The scale assesses the severity of four parkinsonian signs (bradykinesia, gait, tremors, and rigidity) that were averaged to construct a global parkinsonian sign score. Nutrient intakes were assessed at baseline using a validated food frequency questionnaire. The associations between quintiles of antioxidant nutrient intakes and progression of parkinsonian signs were assessed using mixed effects models adjusted for age, sex, education, smoking. Results: In separate adjusted models, a slower rate of progressive parkinsonian signs was observed among those in the highest intake quintiles of total carotenoids (β= −0.06, 95%CI: −0.10 to −0.02,), beta-carotene from foods (β= −0.04, 95% CI:−0.08 to −0.0021), lutein-zeaxanthin (β= −0.05, 95%CI:−0.09 to −0.02), vitamin E from foods (β= −0.04, 95%CI:−0.08 to −0.01,) and vitamin C from foods (β= −0.06, 95%CI:−0.10 to −0.02), when compared to those in the lowest quintiles of intake. Conclusion: A higher level of dietary antioxidant nutrients may slow the rate of parkinsonian sign progression in older adults.