Abstract
BackgroundWe investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants, which have anti-carcinogenic properties, and development of Barrett’s oesophagus (BO) and oesophageal adenocarcinoma (OAC).MethodsA total of 24,068 well individuals completed 7-DFDs and donated blood. Vitamins C and E, carotenes, zinc and selenium intakes, and plasma vitamin C were measured. Participants were monitored for 15 years for BO and OAC. Hazard ratios (HRs) were estimated for: quintiles of intake and in participants younger and >=65 years at recruitment, the midpoint of BO peak prevalence.ResultsA total of 197 participants developed BO and 74 OAC. There were no significant associations between antioxidants and BO or OAC in the whole cohort or if >65 years at recruitment. In participants <65 years, for BO, there was an inverse trend across plasma vitamin C quintiles (trend HR = 0.82; 95% CI = 0.71–0.96, P = 0.01), OAC for plasma vitamin C (trend HR = 0.58; 95% CI = 0.37–0.92, P = 0.02) and for dietary vitamins C and E (trend HR = 0.71 95% CI = 0.51–0.99, P = 0.04 and trend HR = 0.70; 95% CI = 0.51–0.96; P = 0.03).ConclusionsData supports a role for dietary antioxidants prevent BO and OAC, perhaps at the earlier stages of carcinogenesis.
Highlights
The aetiology of both Barrett’s oesophagus (BO) and oesophageal adenocarcinoma (OAC), and the exposures that influence the malignant transformation of BO, is not fully understood
In participants younger than 65 years at recruitment who developed BO, statistically non-significant inverse associations were observed between all quintiles of both food diary assessed and plasma vitamin C, with a significant inverse trend across quintiles for plasma vitamin C and BO risk
For OAC, participants recruited younger than 65 years, there were non-significant inverse associations for all quintiles of both dietary and plasma vitamin C, with significant inverse trends across quintiles for both dietary vitamin C intake and plasma vitamin C
Summary
The aetiology of both Barrett’s oesophagus (BO) and oesophageal adenocarcinoma (OAC), and the exposures that influence the malignant transformation of BO, is not fully understood. We investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants, which have anti-carcinogenic properties, and development of Barrett’s oesophagus (BO) and oesophageal adenocarcinoma (OAC). There were no significant associations between antioxidants and BO or OAC in the whole cohort or if >65 years at recruitment. In participants
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