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Abstract
Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs). In this study, life span was determined for SHRSPs provided 1% NaCl solution or 0.01% GABA in 1% NaCl solution as drinking water. The life span of the GABA-fed group (76.3 ± 1.65 days) was significantly shorter than that of the control group (81.6 ± 0.88 days). The results of this study may not be applicable to humans. Future studies will be necessary to elucidate the mechanism underlying this phenomenon.
Highlights
Introduction γAminobutyric acid (GABA) is an amino acids, found in unpolished rice, fermented food such as tempe, and vegetables
This study aimed to examine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs)
The present study aimed to examine the effect of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs)
Summary
Aminobutyric acid (GABA) is an amino acids, found in unpolished rice, fermented food such as tempe, and vegetables. In humans, it is well recognized as an inhibitory transmitter. Many studies of the effect of GABA on blood pressure have been performed, and dietary GABA has been approved as a “Food for Specific Health Use” in Japan. Dietary GABA may prevent cardiovascular disease such as cerebral stroke, but no study has examined the effect of GABA on stroke onset yet. The present study aimed to examine the effect of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs)
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