Abstract
The promotion of muscle recovery after immobilization is important to preserve an optimum health status. Here, we examined the effect of dietary Alaska pollack protein (APP) on skeletal muscle weight after atrophy induced by hind limb immobilization using plaster immobilization technique. Rat left limb was casted with a wetted plaster cast under anesthesia. After 2 weeks of feeding, the cast was removed and the rats were divided into three groups, namely, a baseline group, high-fat casein diet group, and high-fat APP diet group. After 3 weeks of feeding, the skeletal muscles (soleus, extensor digitorum longus [EDL], and gastrocnemius) were sampled. The estimated weight gains of soleus, gastrocnemius, and EDL muscle in the immobilized limbs were significantly larger in the rats fed with APP diet as compared with those fed with casein diet. In soleus muscle, dietary APP increased the expression of Igf1 and Myog genes in the immobilized limbs after the recovery period.
Highlights
A number of studies have found that unloading or reduced muscle activity induces significant muscle atrophy [1, 2]
Estimated skeletal muscle weight gain during the recovery period of 3 weeks were compared between high-fat casein diet group and high-fat Alaska pollack protein (APP) diet group to evaluate the dietary APP effect on muscle recovery
The estimated weight gains of soleus, gastrocnemius, and extensor digitorum longus (EDL) muscle in the immobilized limbs were significantly larger in the rats fed with APP diet as compared with those fed with casein diet (19%, 26%, and 29% larger, respectively) (Fig 3)
Summary
A number of studies have found that unloading or reduced muscle activity induces significant muscle atrophy [1, 2]. Skeletal muscle has an inherent capacity to recover from atrophy, the maintenance and recovery of muscle mass and function after disuse sometimes can be slow, inefficient and incomplete [3, 4]. Resistance exercise is not always relevant in specific physio-pathological situations. The advancement of alternative approaches to promote muscle recovery following disuse is important. Dietary approaches for the positive effects on muscle recovery after immobilization have been examined. Martin et al reported that recovery kinetics varied between diets and the diet supplemented with whey proteins promoted faster
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