Abstract
Acrylamide is a probable carcinogen in humans. Few studies have assessed dietary acrylamide intake and the risk of pancreatic cancer; however, these studies are based on Western populations. Our purpose was to investigate the association of dietary acrylamide intake with the risk of pancreatic cancer utilizing data from the Japan Public Health Center-based Prospective Study. We evaluated the data of 89,729 participants aged 45–74 years, who replied to a questionnaire on past medical history and lifestyle habits from 1995–1998. Dietary acrylamide intake was estimated utilizing a validated food frequency questionnaire. We calculated the hazard ratios and 95% confidence intervals by using Cox proportional-hazards regression models. The average follow-up was 15.2 years, and 576 cases of pancreatic cancer were diagnosed. In the multivariate-adjusted model, an association between dietary acrylamide intake and pancreatic cancer risk was not demonstrated (hazard ratio for the highest vs. lowest quartile = 0.83, 95% confidence interval: 0.65–1.05, p for trend = 0.07). Furthermore, in the analyses stratified by sex, smoking status, coffee consumption, green tea consumption, alcohol consumption, and body mass index, no significant association was detected. Dietary acrylamide intake was not associated with the pancreatic cancer risk in Japanese individuals.
Highlights
IntroductionThere are a few studies that have investigated the association between pancreatic cancer risk and dietary acrylamide intake
In 1994, acrylamide was classified by the International Agency for Research on Cancer Group as a Nutrients 2020, 12, 3584; doi:10.3390/nu12113584 www.mdpi.com/journal/nutrientsCurrently, there are a few studies that have investigated the association between pancreatic cancer risk and dietary acrylamide intake
Five studies have assessed the association of acrylamide intake with pancreatic cancer [6,7,8,9,10]; no such association has been established. This finding is supported by a recent meta-analysis, which showed that dietary acrylamide intake was not associated with pancreatic cancer risk [11]
Summary
There are a few studies that have investigated the association between pancreatic cancer risk and dietary acrylamide intake. Five studies (two prospective cohort studies, one case-cohort study, one case-control study, and one pooled analysis of six case-control studies) have assessed the association of acrylamide intake with pancreatic cancer [6,7,8,9,10]; no such association has been established. Studies on the association of pancreatic cancer risk with dietary acrylamide, including the stratified analyses, are limited; more studies are needed to support these results
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