Abstract
We previously reported that dietary acrylamide, at doses (10 and 50 mg/kg diet) known to cause rodent tumors, lowered serum total high density lipoprotein and total testosterone, increased serum lipase, and lowered lymphocytes levels together with other hematological parameters in male F344 rats exposed for 10 weeks (doi: 10.1016/j.etap.2014.11.009 [1]). Here we present data related to the role of food-borne acrylamide exposure (at 0, 5, 10 and 50 mg/kg diet) in the presence of low (7% wt/wt) or high (23.9% wt/wt) dietary fat on serum and urinary markers of oxidative stress and inflammation in F344 rats. Briefly, urine and serum samples were collected from the experimental animals a day prior to or at the time of necropsy, respectively and processed for enzyme-linked immunosorbent assay estimations of biochemical markers. Urine samples were analyzed for 8-hydroxydeoxyguanosine and isoprostane, and serum samples for total antioxidant capacity, paraoxonase 1 activity, c-reactive protein, homocysteine, oxidized low-density lipoprotein, intercellular adhesion molecule-1, thromboxin 2, and Nε-(carboxymethyl)lysine.
Highlights
Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada article info
Male F344 rats were fed an AIN À 93 G basal diet containing low fat (7% wt/wt) or high fat (23.9% wt/wt) and 0, 5, 10, or 50 mg/kg diet acrylamide for 8 weeks
We explored the role of chronic exposure to food-borne acrylamide in modulating markers of systemic oxidative stress and inflammation in rats under low and high fat diet conditions
Summary
We explored the role of chronic exposure to food-borne acrylamide in modulating markers of systemic oxidative stress and inflammation in rats under low and high fat diet conditions. This systemic biochemical data will support previous findings of acrylamide exposure at doses known to cause rodent tumors. The present dataset includes results of biochemical estimations that determined markers of systemic oxidative stress and inflammation in urine and serum samples of F344 rats exposed to dietary acrylamide Rats were monitored every day and their body weights and food consumption were recorded twice a week; diets were replenished weekly
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
