Diet selection improves morphine's antinociceptive actions in rats with streptozotocin-induced diabetes.

Abstract

Following the administration of the diabetogenic drug streptozotocin, rats selecting their diet from separate sources of macronutrients (e.g., proteins, fats, and carbohydrates) demonstrated less severe symptoms of diabetes than did rats fed ground Purina chow or a composite diet containing the same nutrient sources as found in the self-selection diet but in the proportions found in chow. After the induction of diabetes, rats selecting their own diet ate and drank less, weighed more, and had more adipose tissue and lower blood glucose levels than did rats consuming chow or the composite diet. In addition, rats choosing their diet were more sensitive to morphine's pain-relieving properties than were rats in the other 2 dietary groups. Rats given the self-selecting diet consumed more protein and fat and less carbohydrate than did those eating a single diet. Data suggest that rats must select their diet preceding and following the induction of diabetes for amelioration of diabetic symptoms to occur. These results indicate that diet can contribute to the severity of diabetes and could be used as an adjunct to standard treatment of the disease.