Abstract
The influence of diet palatability and caloric density on amphetamine anorexia was examined in two experiments. In Experiment 1, rats were offered a palatable but hypercaloric high-fat diet, a chow diet, a pellet diet, or a palatable mineral-oil diet equal in caloric density to the chow and pellet diets. Although the rats displayed differential acceptance of the diets during saline intake tests, identical percent changes in intake with amphetamine treatment (1.0, 2.0, and 4.0 mg/kg) were observed. In a second experiment, rats were offered the chow and mineral-oil diets in a preference sequence before and after intake testing to ensure that these diets were indeed different in palatability. Although the rats displayed a considerable preference for the mineral-oil diet over the chow diet, comparable percent changes in diet intake with amphetamine (.25,.50, 1.0, and 2.0 mg/kg) were observed. These data, therefore, did not support the notion that enhancement of diet palatability may offset the anorexic property of amphetamine but did support a malaise interpretation of amphetamine anorexia.
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