Abstract
Lifestyle interventions remain the first-line treatment for non-alcoholic fatty liver disease (NAFLD), even if the optimal alimentary regimen is still controversial. The interest in antioxidants has increased over time, and literature reports an inverse association between nutrients rich in antioxidants and the risk of mortality due to non-communicable diseases, including NAFLD. Mediterranean diet (MD) is a model characterized by main consumption of plant-based foods and fish and reduced consumption of meat and dairy products. MD represents the gold standard in preventive medicine, probably due to the harmonic combination of many foods with antioxidant and anti-inflammatory properties. This regimen contributes substantially to the reduction of the onset of many chronic diseases as cardiovascular diseases, hypertension, type 2 diabetes mellitus, obesity, cancer, and NAFLD. The present review aims to clarify the intake of antioxidants typical of the MD and evaluate their effect on NAFLD.
Highlights
Non-alcoholic fatty liver disease (NAFLD), is the hepatic manifestation of the metabolic syndrome associated with obesity [1]
It remains clear how adherence to the Mediterranean diet (MD) increases quality and life expectancy by reducing the risk of death, related to higher content of antioxidants and polyphenols mainly present in foods rich in fiber. It leads to a modulation of the gut microbiota that influences, and it is influenced by, the polyphenols and the foods that contain them [36,37]
The MD seems to be the ideal diet for patients with non-alcoholic fatty liver disease (NAFLD), thanks to its effectiveness on the liver status that leads to the improvement of insulin sensitivity and lipid profile, and to be a primary form of prevention for metabolic related diseases [16,46]
Summary
Non-alcoholic fatty liver disease (NAFLD), is the hepatic manifestation of the metabolic syndrome associated with obesity [1]. High body mass index, is a pivotal risk factor for steatosis, suggesting that excess caloric intake and obesity contribute to NAFLD development [1,7]. The health properties and beneficial effects of MD in patients with NAFLD, have been described for liver steatosis and metabolic dysfunction, based on observational studies and short-term trials with consistent results [16]. This narrative review aims to describe current acknowledgments and to highlight new perspectives, on the use of MD in patients with NAFLD and its related metabolic features
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
