Diels-Alder reaction of N-allylic enamides and lactam derivatives through iodine mediated activation

Abstract

The Diels-Alder reaction of N-allylic enamide and α,β-unsaturated lactam derivatives proceeded in the presence of I 2 at low temperature through a cationic iodolactonization intermediate. With some substrates, this method of activation was proved to be more effective than by use of Lewis acids.