Abstract
AbstractThe Diels–Alder reaction is probably, together with aldol condensation, the most commonly used reaction in chemistry. The Diels–Alder approach, which involves a diene and a dienophile not present in any biomolecule, allows a chemoselective reaction without the need of protecting groups. Moreover, water has an extraordinary rate‐accelerating effect on the reaction process. Thus, this chemical approach has been recognized as a promising procedure for protein bioconjugation. In this review some of the most recent advances in the application of the Diels–Alder reaction in selective surface modification, immobilization and biocatalysis will be discussed.
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