Abstract
Zusammenfassung A method for the quantitative determination of Δ4-17β-hydroxyestrene derivatives has been worked out. The estrenols are first separated by thin-layer chromatography and after localisation with iodine vapour, the steroid spots are extracted. The residue from the evaporated extract is then determined by a colorimetric method, using sulphuric acid or vanillin-sulphuric acid as reagent. With this method the stability of tablets containing 17α-ethyl-, 17α-allyl- or 17α-ethinylestrenol has been tested. As has been shown with ethylestrenol tablets, there are large differences in stability depending on the excipients and the chosen stabiliser. However, the stability of the estrenol tablets tested, which were stabilised with different suitable additives, was found to be quite good.
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