Abstract
The proteolytic activity of purulent secretions from acute and chronic middle ear infections, Cholesteatoma and radical mastoid cavities were investigated. High proteolytic activity per mg of lyophilized secretion can be measured. The proteinase inhibitors which inactivate part of the mainly leucocytic, proteinase, were determined. The proteinase occur in excess, however, and produce pathogenic activity. The proteolytic activity is higher in the secretions from Cholesteatoma and from radical cavities than during acute otitis media and is also higher than in the purulent secretions from inflamed maxillary sinuses. The proteinases are of clinical interest in that they play a part in ossicular destruction.
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