Abstract
Ceruloplasmin isolated from human serum could be separated in two components (C-C and C-D) which showed marked differences concerning their physico-chemical properties. From sedimentation studies a molecular weight of 148000 was calculated for C-C and of 125 000 for C-D. Fraction C-C contained 8 and C-D 6 moles Cu/mole enzyme. Different amounts of carbohydrates were found in both forms (C-C, 7%; C-D, 3.2%). The different behaviour in the electrophoretic mobility on starch gel as well as in the immuno-electrophoresis gave further evidence that two distinct forms of ceruloplasmin exist. The possibility that fraction C-D may serve a of precursor of C-C has been discussed.
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