Abstract
Changes in the uptake of 3H-estradiol by the brain, pituitary and uterus of rats from birth to sexual maturity were studied by liquid scintillography and autoradiography. Scintillography demonstrated a preferential uptake of radioactivity in the median eminence and anterior hypothalamus occurring in 15 and 20-day-old females, respectively. Autoradiography, however, revealed different changes in the anterior hypothalamic complex, a decrease in concentration of radioactivity in the preoptic-suprachiasmatic region between the age of 15 and 20 days and the first appearance of the radiochemical in the anterior hypothalamic area between the age of 10 and 15 days simultaneously with its diappearance from the amygdala.
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