Abstract
For 30 basic drugs an investigation was made of the relationship between structure and behaviour on paper chromatography in the reverse phase system petroleum/ethanol—water—ammonia. Using seven mobile phases that differed in ethanol content, the influence of the composition of the mobile phase on the alteration of the R F value was studied. It was found that for tertiary bases the R F increased with increasing ethanol content of the mobile phase, whereas for quaternary bases the R F decreased. Only three exceptions to this rule were found among the 30 compounds investigated (20 compounds with tertiary and 10 with quaternary nitrogen). The influence of temperature on the change in R F value was also investigated for this system. Conditions were established for obtaining the best separation of compounds that have similar structures or almost identical R F values.
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