Abstract
The release of tritium-labelled diclofenac from 3D matrices produced by electrospinning from polycaprolactone or PCL blends with human serum albumin in hexafluoroisopropanol was studied. Diclofenac is released significantly faster from matrices made from PCL solution with 10% HSA than from matrices made from pure PCL. Diclofenac was also released faster into blood plasma than into PBS, and the presence of diclofenac in the medium reduced the release rate, as indicated by experiments with regular medium replacement. Thus, diclofenac release depends on the composition of electrospinning solution, the nature of the external medium and the diclofenac concentration in the external medium.
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