Dickeya Manipulates Multiple Quorum Sensing Systems to Control Virulence and Collective Behaviors.

Yang Xue,Jianuan Zhou,Anqun Hu,Lian-Hui Zhang,Zhijia Zhang,Shanshan Chen,Ming Hu,Fan Liu

doi:10.3389/fpls.2022.838125

Yang Xue, Jianuan Zhou + Show 6 more

Open Access

https://doi.org/10.3389/fpls.2022.838125

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Abstract

Soft rot Pectobacteriaceae (SRP), typical of Pectobacterium and Dickeya, are a class of Gram-negative bacterial pathogens that cause devastating diseases on a wide range of crops and ornamental plants worldwide. Quorum sensing (QS) is a cell-cell communication mechanism regulating the expression of specific genes by releasing QS signal molecules associated with cell density, in most cases, involving in the vital process of virulence and infection. In recent years, several types of QS systems have been uncovered in Dickeya pathogens to control diverse biological behaviors, especially bacterial pathogenicity and transkingdom interactions. This review depicts an integral QS regulation network of Dickeya, elaborates in detail the regulation of specific QS system on different biological functions of the pathogens and hosts, aiming at providing a systematic overview of Dickeya pathogenicity and interactions with hosts, and, finally, expects the future prospective of effectively controlling the bacterial soft rot disease caused by Dickeya by quenching the key QS signal.

Highlights

Soft rot Pectobacteriaceae (SRP) belonging to the genera Pectobacterium and Dickeya (Charkowski et al, 2012) are emerging parasitic pathogens listed in the top ten important bacterial phytopathogens in the world (Mansfield et al, 2012)
Previous studies have revealed that the acyl-homoserine lactone (AHL)-Quorum sensing (QS) system regulates the cell motility and biofilm formation of Dickeya spp., playing an essential role in pathogen colonization and survival in poor environmental conditions (Hussain et al, 2008; Feng et al, 2019), while the VFMQS system is more dominant in regulating the production of diverse virulence factors and the ability to macerate plant tissue (Nasser et al, 2013; Lv et al, 2019)
The results showed that the two QS systems do not coordinate the virulence of Dickeya (Potrykus et al, 2018)

Summary

INTRODUCTION

Soft rot Pectobacteriaceae (SRP) belonging to the genera Pectobacterium and Dickeya (Charkowski et al, 2012) are emerging parasitic pathogens listed in the top ten important bacterial phytopathogens in the world (Mansfield et al, 2012). Different structures of virulence factor modulating (VFM)-quorum sensing (QS) signals were implicated between D. dadantii 3937 and D. oryzae EC1 and D. zeae banana strains (Lv et al, 2019). During the growth of D. oryzae EC1, the production of VFM signal was quantified, and the results showed that when the cell density is lower than OD600 at 0.5, the VFM signal increased slowly with the increase of bacterial concentration; when the cell density is over OD600 at 0.5, the signal generation rate is obviously accelerated; after OD600 at 1.2, interestingly, the signal concentration decreased sharply (Lv, 2018), suggesting that VFM signal degrading enzymes are probably present in the TABLE 1 | Homologs of the luxR-solo systems (C1O30_RS14500 to C1O30_RS14535) of Dickeya zeae MS2. Guangzhou NA France: Durance River China: Guangzhou United States: Hawaii United States: Hawaii China: Meizhou Zhejiang Malaysia Germany Poland Netherlands Finland France Netherlands Comoros NA United States:Maine NA Hunan United Kingdom

United States Sydney NA NA South Korea NA South Korea Japan

CONCLUSION