Abstract
Dicitrinone D is a novel polyketide isolated from a marine-derived fungus Penicillium citrinum. In this study, we described the isolation, structure elucidation and antitumor mechanism of this compound. Cell proliferation assay showed that dicitrinone D was safe for normal cells, but effectively inhibited the growth of multiple tumor cells, especially SPC-A1 cells. Cell cycle and immunofluorescence analysis suggested that dicitrinone D had cellular effects similar to other microtubule-targeting agents. Polymerization assay, electron microscopy and time-lapsed video microscopy assay demonstrated dicitrinone D was a microtubule-destabilizing agent. Finally, the docking analysis predicted that dicitrinone D may bind to vinblastine binding site on tubulin.
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