Abstract
Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4–6, 10–11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, and SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity against α-glucosidase with an IC50 of 138 μM.
Highlights
Marine microorganisms are a rich source of structurally unique and bioactive metabolites.Even considering the trend of recent years that many marine natural products research efforts are directed towards microorganisms, there has been a sharp upward swing in the number of new metabolites reported from marine microorganisms [1,2]
Thousands of natural products with diverse structural types have been reported from marine flora and fauna, the secondary metabolites derived from the deep-sea fungi at depths of over 1000 m below the surface are limited [3,4]
In our ongoing effort to search for structurally diverse and biologically significant metabolites from deep-sea fungi [5,6,7,8], we found that a culture broth of Dichotomomyces cejpii
Summary
Marine microorganisms are a rich source of structurally unique and bioactive metabolites.Even considering the trend of recent years that many marine natural products research efforts are directed towards microorganisms, there has been a sharp upward swing in the number of new metabolites reported from marine microorganisms [1,2]. Deep-sea organisms survive under extreme conditions such as an absence of light, low levels of oxygen, and intensely high pressures. These factors may result in the production of structurally unique secondary metabolites. Thousands of natural products with diverse structural types have been reported from marine flora and fauna, the secondary metabolites derived from the deep-sea fungi at depths of over 1000 m below the surface are limited [3,4]. In our ongoing effort to search for structurally diverse and biologically significant metabolites from deep-sea fungi [5,6,7,8], we found that a culture broth of Dichotomomyces cejpii
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