Dichloromethane metabolism to carbon monoxide can be induced by isoniazid, acetone and fasting.

Abstract

Pretreatment of rats with isoniazid (INH) produced an elevation of dichloromethane (DCM) metabolism to carbon monoxide (CO) as measured by carboxyhemoglobin (COHb) formation (Pankow 1988). INH induced an isozyme of cytochrome P-450 that is different from those induced by phenobarbital or 3-methylcholanthrene (Rice and Talcott 1979) and that is distinct from nine other rat hepatic microsomal cytochromes P-450 (P-45Oa-P-45Oi) and therefore designated as cytochrome P-450j (Ryan et al 1985). This isozyme can also be induced by acetone (Koop and Casazza 1985) or by fasting (Hong et al 1987). The results presented in this paper show that DCM metabolism to CO can be induced by INH, acetone, and fasting.KeywordsCarbon MonoxideOxygen InsertionBlood SampiesIndustrial ToxicologyIsoniazid TreatmentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.