Abstract
Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice
Highlights
In the pathogenesis of a variety of human diseases including diabetes mellitus, oxidative stress and subsequent oxidative damage to tissues have been involved [1]
Effect of PFDCM on lipid peroxidation A significant increase in thiobarbituric acid-reactive substances (TBARS) level was seen in the liver, and kidney of the untreated diabetic group compared to the normal group (Fig. 1)
TBARS level in the liver was increased by 101% (p < 0.001) and in the kidney by 63% (p < 0.001) above that of the normal group
Summary
In the pathogenesis of a variety of human diseases including diabetes mellitus, oxidative stress and subsequent oxidative damage to tissues have been involved [1]. ROS activates nuclear transcription factor NF-κB [7]. This in turn facilitates the up-regulation of multiple NF-κB regulated target genes [8] and leads to the negative impact of inflammatory diabetes reactions on the tissue [9]. PPAR-γ, a nuclear receptor that is active in the etiology of type II diabetes, controls NF-κB [10]. It plays an important role in adipogenesis and insulin sensitivity and is triggered by fatty acids [8]
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