Abstract

[35739-70-9] C2H6Cl2Ti (MW 148.86) (Lewis acidic reagent2 capable of geminal dimethylation of ketones3 and aromatic aldehydes,4 substitution reactions of tertiary alkyl halides and alcohols,5 and stereoselective Grignard-type additions to aldehydes and ketones6-9) Physical Data: reliable data not available; dark violet in crystalline form (dec. at −10 °C); yellow in hydrocarbon solvents; violet in diethyl ether. Preparative Methods: several methylmetal reagents such as Methyllithium, Methylmagnesium Bromide, Me2Zn, and Trimethylaluminum react stoichiometrically with Titanium(IV) Chloride to form Me2TiCl2.1-3 In the presence of ether, the Lewis acidic compound forms etherates. For a number of synthetic organic applications, ether-free solutions of Me2TiCl2 are required.1, 3, 5 In these cases, the preparation of choice is the reaction of Me2Zn with TiCl4 in dry CH2Cl2 (eq 1).3, 5 Caution: Although Me2Zn is highly pyrophoric, CH2Cl2 solutions are less so and are easy to handle.3 (1) Handling, Storage, and Precautions: although Me2TiCl2 can be crystallized, it is best not to isolate the compound (due to its thermal lability and light sensitivity). In situ reaction modes under an inert gas atmosphere (e.g. argon) in the absence of direct sunlight are recommended.

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