Abstract

FSCJ conducted the risk assessment of a fungicide, dichlobentiazox (CAS No.957144-77-3), having benzoisothiazole and isothiazole rings, based on results from various studies.The data used in the assessment include fate in animals (rats) and in livestock (goats), fate in plants (paddy rice), residues in crops, subacute toxicity (rats, mice and dogs), chronic toxicity (dogs), carcinogenicity (rats and mice) and other relevant study results. This chemical showed none of carcinogenicity, reproductive toxicity, teratogenicity and genotoxicity. The lowest no-observed-adverse-effect level (NOAEL) obtained in all studies was 5.03 mg/kg bw per day in a two-year chronic toxicity/carcinogenicity study in rats. FSCJ specified an acceptable daily intake (ADI) of 0.05 mg/kg bw per day by applying a safety factor of 100 to the NOAEL.

Highlights

  • FSCJ conducted the risk assessment of a fungicide, dichlobentiazox (CAS No.957144-77-3), having benzoisothiazole and isothiazole rings, based on results from various studies.The data used in the assessment include fate in animals and in livestock, fate in plants, residues in crops, subacute toxicity, chronic toxicity, carcinogenicity and other relevant study results

  • The data used in the assessment include fate in animals and in livestock, fate in plants, residues in crops, subacute toxicity, chronic toxicity. chronic toxicity/carcinogenicity, carcinogenicity, two-generation reproductive toxicity, developmental toxicity, and genotoxicity

  • The original full report is available in Japanese at http://www.fsc.go.jp/fsciis/attachedFile/download?retrievalId=kya20181121129&fileId=210 Suggested citation: Food Safety Commission of JAPAN

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Summary

Introduction

FSCJ conducted the risk assessment of a fungicide, dichlobentiazox (CAS No.957144-77-3), having benzoisothiazole and isothiazole rings, based on results from various studies.The data used in the assessment include fate in animals (rats) and in livestock (goats), fate in plants (paddy rice), residues in crops, subacute toxicity (rats, mice and dogs), chronic toxicity (dogs), carcinogenicity (rats and mice) and other relevant study results. FSCJ conducted the risk assessment of a fungicide, dichlobentiazox (CAS No.957144-77-3), having benzoisothiazole and isothiazole rings, based on results from various studies. Major adverse effects of dichlobentiazox were suppressed body weight, anemia (dogs), hyperplasia and hypertrophy of bile duct in the liver, and epithelial hypertrophy/hyperplasia of villus in the duodenum.

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Conclusion
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