Abstract
Dicentric Chromosome Assay (DCA) is a validated biodosimetry technique. It has been used to determine previous exposure to radiation by measuring chromosome damage in Tcells that have lifespan of about 3 years. Association of increased background dicentric chromosomes (DC) and risk of cancer development has been reported before. Previously, we reported results supporting radiation induced DC and excess fragments (EF) as potential biomarkers of increased radiosensitivity. In this study we studied number of DCs and EFs in a cohort of cancer patients cancer to assess that as a marker of cancer susceptibility.
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