Abstract
A general method was developed to construct monocyclic α-methylene-γ-butyrolactone moiety. The key step is to introduce the α-methylene group by the ozonolysis of mono-substituted alkenes followed by reacting with a preheated mixture of CH 2Br 2–Et 2NH. Application of this key step in the total synthesis of the (±)- and (−)-methylenolactocin was described.
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