Diazepinone effect on liver tissue respiration and serum lipid content in rats with a rotenone model of Parkinson’s disease

L Ya Shtanova,S P Vesеlsky,P I Yanchuk

doi:10.15407/ubj92.06.085

L Ya Shtanova, S P Vesеlsky + Show 1 more

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https://doi.org/10.15407/ubj92.06.085

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Abstract

Diazepinone effect on liver tissue respiration and serum lipid content in rats with a rotenone model of Parkinson’s disease

Highlights

Parkinson’s disease (PD) is a neurodegenerative disorder, which is a major health problem worldwide
Degeneration of dopaminergic neurons has been long associated with the accumulation and aggregation of α-synuclein in axons and synapses, oxidative stress and mitochondrial dysfunction that are believed to play a major role in the etiopathogenesis of PD [6,7,8]
The purpose of this study was to investigate: 1) the features of liver functioning in rats with PD modeled by ROT, in particular liver tissue respiration (LTR), as well as lipid metabolism, the synthesis of which directly depends on the state of energy metabolism in hepatocytes; 2) corrective influence of the new synthetic therapeutic agent diazepinone on tissue respiration indicators and on the level of different lipids in the blood plasma of rats with PD simulated by ROT

Summary

Introduction

Parkinson’s disease (PD) is a neurodegenerative disorder, which is a major health problem worldwide. It has been shown that a third of PD patients are affected by depression, which is combined with anxiety and apathy, further complicating the course of PD [5] These symptoms are associated with a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, which results in a significant reduction in dopamine levels in the striatum. In the long run they cause some serious side effects, such as mental and motor complications [12] In this context, the drugs with the ability to modulate mitochondrial function and biogenesis may have important clinical significance in the future treatment of PD. Preliminary studies have shown that in rats with the ROT model of PD a new drug, 2,3-diazepine had correcting effects on liver tissue respiration and bile secretory function [15]

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