Abstract
Benzodiazepines (BZDs) exert their antiepileptic, anxiogenic, and somnogenic effects by binding to GABA-A receptors (GABARs). GABARs are inhibitory pentameric ligand-gated channels commonly formed by 2α, 2β and 1γ subunits, though some GABARs are formed by only α and β subunits. The high-affinity binding site for BZDs is located in the extracellular domain between the α and γ subunits and is absent in αβ receptors.
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