Abstract
The carbometalation reaction of allyl- and crotylzinc bromide with metalated disubstituted homoallylic ethers gives tri- or tetrasubstituted 5-hexenyl ethers with excellent control of the diastereoselectivity. The stereochemistry of this reaction is discussed and has been attributed to an early transition state with chelation to the oxygen atom in the energetically favored conformer as the stereodetermining step.
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