Abstract

Conjugate additions of MeCu, PhCu and BuCu to the chiral enoylimides 2 a-c in the presence of iodotrimethylsilane and lithium iodide in THF give the adducts, 4a-c in yields above 90 % and diastereoselectivities from 80 to 93%. The dominating diastereomers are different from those formed with LiR 2Cu/TMSCl or in copper(I)-mediated addition of Grignard reagents. Corresponding additions to enoylamides of O- tritylprolinol also give high yields of conjugate adducts, but lower diastereoselectivities, with dominating configuration in the acyl part opposite to those from the imides.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call