Abstract
The construction of N-heterocyclic eight-membered rings remains challenging due to unfavorable transannular strain. Herein, we report a Lu(OTf)3-catalyzed formal [4+4] cycloaddition reaction of cyclobutane 1,1-diesters with anthranils to deliver oxa-bridged eight-membered heterocycles. This methodology provides great potential to build complex azocine compounds from simple building blocks. Based on our preliminary mechanism studies, a probable mechanism for this annulation pathway has been proposed.
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