Abstract
An efficient DMAP catalyzed tandem aldol/imidization reaction of α-isothiocyanato esters with α-ketoamides is described, affording ring-fused thiocarbamates bearing contiguous quaternary carbon centers with up to 99% yield in a completely diastereoselective fashion. This method has a wide range of substrate scope and can be used in the synthesis of pyrrolidines.
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