Diastereoselective synthesis of a hydroxamate containing bicyclo-[3.2.0] β-lactam aminal via ruthenium alkene isomerization and Pd(II)-catalyzed oxidative amidation

Abstract

With antibiotic resistance on the rise, the need for new medicinal scaffolds is needed. The synthesis of an aminal bicyclic β-lactam core is described. The key synthetic step is Pd(II)-catalyzed oxidative amidation. The product is a single diastereomer, confirmed by X-ray crystallography.