Abstract
AbstractA facile and practical method has been developed for the stereoselective synthesis of coumarin‐4‐carboxamido‐3‐esters via a four‐component reaction between salicylaldehyde, malonic acid, alkyl or aryl isocyanides and various alcohols in acetonitrile at room temperature. Coumarin derivatives have been introduced to be effective in inhibition of cyclooxygenase pathways thus; the potential of new products for interaction into cyclooxygenase enzymes (COX‐1/COX‐2) was screened via in silico molecular docking towards the original compound as an assist for designing the potent inhibitors in the future studies.
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