Diastereoselective nucleophilic addition to chiral open-chain α-ketoacetals: Synthesis of (R)- and (S)-mevalolactone

Abstract

Highly stereoselective addition of Grignard reagents to chiral open-chain α,-ketoacetals ( 3a , 3b ) has been attained. Application of the reaction to syntheses of the key intermediates ( 6 , 8 ) for (R)- and (S)-mevalolactone is also described.