Abstract
AbstractCu–Taniaphos‐catalyzed enantioselective addition of Grignard reagents to cyclic enones leads to chiral magnesium enolates. These enolates add to N‐protected imines directly, or through in situ transformation to silyl enol ethers. Diastereoselectivity of the addition depends on the nitrogen protecting group of the imine. Diastereoisomers of the resulting β‐amino carbonyl compounds can be separated and are obtained in acceptable yields and in high enantiomeric purities (up to 99:1 er).
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