Abstract
[reaction: see text] Stereocontrolled intramolecular alpha-amidoalkylation reactions of L-DOPA-derived succinimides have been studied. Addition of MeLi to nonracemic succinimides 9a-d yields oxoamides, which are cyclized upon treatment with Lewis or protic acids to afford (5S,10bS)-trans 11 or (5S,10bR)-cis 12pyrroloisoquinolines with variable diastereoselectivities, but with high enantiomerical purities (ee 99%).
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