Diastereoselective and Enantioselective Synthesis of Multi‐Functionalized Isoxazoline‐N‐Oxides through Asymmetric [4+1] Annulations

Abstract

AbstractA diastereoselective and enantioselective formal [4+1] ylide annulation of chiral sulfonium salts with various substituted Morita‐Baylis‐Hillman (MBH) adducts leading to optically active isoxazoline N‐oxides with three chiral carbon centers has been explored. The salient features of this methodology include a high diastereo‐ and enantioselective transformation, easily accessible starting materials, and mild reaction conditions. In addition, the isoxazoline N‐oxides products can be conveniently transformed into functionalized compounds.