Abstract
AbstractAn efficient catalytic asymmetric epoxidation of β‐trifluoromethyl‐β,β‐disubstituted unsaturated ketones has been achieved by a pentafluorine‐substituted phase‐transfer catalyst with hydrogen peroxide (30%). Thus, the β‐trifluoromethyl‐α,β‐epoxy ketones with a quaternary carbon centre were obtained in excellent diastereoselectivities (up to 100:1 dr) and excellent enantioselectivities (up to 99.7% ee). Low catalyst loading, recycle of catalyst, environmentally benign oxidant and easy transformation of the epoxides into medicinally important trifluoromethylated intermediate make our protocol much more practical.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.