Abstract
241 patients who had gastrointestinal operations were studied prospectively. Postoperative diarrhœa occurred in 58 patients (24%) and was significantly more common after exposure to antibiotics. 9 patients (4%) had high titres of a neutralisable fæcal toxin characteristic of pseudomembranous colitis. Toxigenic Clostridium difficile strains were isolated from the stools of all patients with neutralisable fæcal toxin. If pseudomembranous colitis is defined as the presence of neutralisable fæcal toxin, then the diagnosis is often missed by sigmoidoscopy and rectal biopsy.
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