Abstract

BackgroundDiaphragm ultrasound (DUS) is a well-established point of care modality for assessment of dimensional and functional aspects of the diaphragm. Amongst various measures, diaphragmatic thickening fraction (DTf) is more comprehensive. However, there is still uncertainty about its capability to predict weaning from mechanical ventilation (MV). The present prospective observational exploratory study assessed the diaphragm at variable negative pressure triggers (NPTs) with US to predict weaning in ICU patients.MethodsAdult ICU patients about to receive their first T-piece were included in the study. Linear and curvilinear US probes were used to measure right side diaphragm characteristics first at pressure support ventilation (PSV) of 8 cmH2O with positive end expiratory pressure (PEEP) of 5 cmH2O against NPTs of 2, 4, and 6 cmH2O and then later during their first T-piece. The measured variables were then categorized into simple weaning (SW) and complicated weaning (CW) groups and their outcomes analyzed.ResultsSixty-four (M:F, 40:24) medical (55/64, 86%) patients were included in the study. Sepsis of lung origin (65.5%) was the dominant reason for MV. There were 33 and 31 patients in the SW and CW groups, respectively. DTf predicts SW with a cutoff ≥ 25.5, 26.5, 25.5, and 24.5 for 2, 4, and 6 NPTs and T-piece, respectively, with ≥ 0.90 ROC AUC. At NPT of 2, DTf had the highest sensitivity of 97% and specificity of 81% [ROC AUC (CI), 0.91 (0.84–0.99); p < 0.001].ConclusionsDTf may successfully predict SW and also help identify patients ready to wean prior to a T-piece trial.

Highlights

  • Diaphragm ultrasound (DUS) is a well-established point of care modality for assessment of dimensional and functional aspects of the diaphragm

  • We proposed to confirm the utility of DUS to assess muscle function in response to a maximal volitional inspiratory effort

  • At negative pressure triggers (NPTs) of 2, diaphragmatic thickening fraction (DTf) had the highest sensitivity of 97%, albeit 81% specificity [ROC AUC, 0.91 (0.84–0.99); p < 0.001] compared to AMP and Speed of contraction (SPcont)

Read more

Summary

Introduction

Diaphragm ultrasound (DUS) is a well-established point of care modality for assessment of dimensional and functional aspects of the diaphragm. There is still uncertainty about its capability to predict weaning from mechanical ventilation (MV). The present prospective observational exploratory study assessed the diaphragm at variable negative pressure triggers (NPTs) with US to predict weaning in ICU patients. Weaning from mechanical ventilation (MV) is one of the major challenges faced by intensivists. Premature [1, 2] and delayed [3, 4] weaning are both detrimental in patients admitted in the intensive care unit (ICU). Weaning consumes approximately 40% time of ventilation [5]. While majority weaning is simple, difficult weaning is encountered in 20–25% of patients [6]. Diaphragm dysfunction results in prolonged MV, weaning failure [13, 14], and increased mortality [15]

Methods
Results
Discussion
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call